Archive
Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
Sign up MyPHGKB to receive the daily hot topic email alert.
Archived Hot Topics of the Day By Date
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies.
Fulya Akçimen et al. Nat Rev Genet 2023 4 (9) 642-658
(Posted: Mar 27, 2024 1PM)
Rare variant and polygenic analyses of amyotrophic lateral sclerosis in the French-Canadian genome
JP Ross et al, Genetics in Medicine, August 25, 2023
(Posted: Aug 25, 2023 8AM)
At-home wearables and machine learning sensitively capture disease progression in amyotrophic lateral sclerosis
AS Gupta et al, Nature Comm. August 21, 2023
(Posted: Aug 22, 2023 9AM)
Wearable device and smartphone data quantify ALS progression and may provide novel outcome measures
SA Johnson et al, NPJ Digital Medicine, March 6, 2023
(Posted: Mar 06, 2023 6PM)
Integrative genetic analysis illuminates ALS heritability and identifies risk genes.
Megat Salim et al. Nature communications 2023 1 (1) 342
(Posted: Jan 24, 2023 8AM)
ALS therapy hits molecular mark but misses clinical one
K O'Leary, Nature Medicine, October 3, 2022
(Posted: Oct 03, 2022 8AM)
Biomarker data prove critical for ALS drug evaluation at FDA.
Carvalho Thiago et al. Nature medicine 2022 9
(Posted: Oct 01, 2022 7AM)
A machine-learning based objective measure for ALS disease severity
FG Vieira et al, NPJ Digital Medicine, April 8, 2022
(Posted: Apr 09, 2022 2PM)
Predictive genetic testing for Motor neuron disease: time for a guideline?
A McNeil et al, EJHG, April 5, 2022
(Posted: Apr 05, 2022 7AM)
Amyotrophic lateral sclerosis - insight into susceptibility.
Todd Tiffany W et al. Nature reviews. Neurology 2022 2
(Posted: Mar 20, 2022 1PM)
New antisense oligonucleotide therapies reach first base in ALS
A Lopez, Nature Medicine, January 24, 2022
(Posted: Jan 26, 2022 7AM)
Genetic counselling and testing for neurodegenerative disorders using a proposed standard of practice for ALS/MND: diagnostic testing comes first
A Crook et al, EJHG, January 5, 2022
(Posted: Jan 05, 2022 9AM)
Translating amyotrophic lateral sclerosis genes into drug development leads
S Sahdeo et al, Nature Genetics, December 10, 2021
(Posted: Dec 11, 2021 8AM)
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
W van Rheenen et al, Nature Genetics, December 6, 2021
(Posted: Dec 07, 2021 7AM)
Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis
P Mohassel et al, Nature Medicine, May 2021
(Posted: Jun 02, 2021 10PM)
Polygenic risk score analysis for amyotrophic lateral sclerosis leveraging cognitive performance, educational attainment and schizophrenia
R Restuadi et al, EJHG, April 27, 2021
(Posted: Apr 27, 2021 8AM)
Value of systematic genetic screening of patients with amyotrophic lateral sclerosis.
Shepheard Stephanie R et al. Journal of neurology, neurosurgery, and psychiatry 2021 Feb
(Posted: Feb 19, 2021 10AM)
Opening the door to gene therapy for ALS
H Stower, Nature Medicine, August 7, 2020
(Posted: Aug 10, 2020 8AM)
ALS Research Notification for Clinical Trials and Studies
CDC/ATSDR, July 2020
(Posted: Jul 21, 2020 7AM)
The Beginning of Genomic Therapies for ALS.
Hardiman Orla et al. The New England journal of medicine 2020 Jul (2) 180-181
(Posted: Jul 09, 2020 9AM)
Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS.
Miller Timothy et al. The New England journal of medicine 2020 Jul (2) 109-119
(Posted: Jul 09, 2020 9AM)
SOD1 Suppression with Adeno-Associated Virus and MicroRNA in Familial ALS.
Mueller Christian et al. The New England journal of medicine 2020 Jul (2) 151-158
(Posted: Jul 09, 2020 9AM)
Prediction of caregiver burden in amyotrophic lateral sclerosis: a machine learning approach using random forests applied to a cohort study.
Antoniadi Anna Markella et al. BMJ open 2020 Feb 10(2) e033109
(Posted: Mar 04, 2020 9AM)
The ALS Registry: Hope for Patients, Resources for Research
CDC,October 2019
(Posted: Oct 16, 2019 5AM)
ALS gene may be a hitchhiker’s guide to the neuron
NIH, September 19, 2019
(Posted: Sep 21, 2019 1PM)
Mutations in the SPTLC1 gene are a cause of amyotrophic lateral sclerosis that may be amenable to serine supplementation
JO Johnson et al, BioRXIV, September 19, 2019
(Posted: Sep 20, 2019 8AM)
Update on amyotrophic lateral sclerosis genetics.
Brenner David et al. Current opinion in neurology 2019 Jul
(Posted: Jul 31, 2019 9AM)
Rare variants in MYH15 modify amyotrophic lateral sclerosis risk
Kin H. et al. Human Molecular Genetics, Volume 28, Issue 14, 15 July 2019, Pages 2309?2318
(Posted: Jul 15, 2019 3PM)
I have ALS. I wish a polygenic analysis had told me it was coming
R Desikan, Stat News, April 30, 2019
(Posted: Apr 30, 2019 1PM)
Lack of consensus in ALS genetic testing practices and divergent views between ALS clinicians and patients.
Klepek Holly et al. Amyotrophic lateral sclerosis & frontotemporal degeneration 2019 Apr 1-6
(Posted: Apr 03, 2019 9AM)
Partitioning the genetic architecture of amyotrophic lateral sclerosis
IJ Broce et al, BioRXIV, February 24, 2019
(Posted: Feb 25, 2019 9AM)
RNA-Seq profiling in peripheral blood mononuclear cells of amyotrophic lateral sclerosis patients and controls.
Zucca Susanna et al. Scientific data 2019 Feb 190006
(Posted: Feb 19, 2019 10AM)
Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis.
Bandres-Ciga Sara et al. Annals of neurology 2019 Feb
(Posted: Feb 19, 2019 10AM)
Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects.
Mitra Joy et al. Proceedings of the National Academy of Sciences of the United States of America 2019 Feb
(Posted: Feb 19, 2019 10AM)
Younger age of onset in familial amyotrophic lateral sclerosis is a result of pathogenic gene variants, rather than ascertainment bias.
Mehta Puja R et al. Journal of neurology, neurosurgery, and psychiatry 2018 Sep
(Posted: Feb 15, 2019 9AM)
Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid.
Otake Kentaro et al. BMC medical genomics 2019 Jan (1) 7
(Posted: Jan 14, 2019 9AM)
Prevalence of Amyotrophic Lateral Sclerosis - United States, 2015.
Mehta Paul et al. MMWR. Morbidity and mortality weekly report 2018 Nov (46) 1285-1289
(Posted: Nov 26, 2018 11AM)
Causal Effects of Blood Lipids on Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study.
Zeng Ping et al. Human molecular genetics 2018 Nov
(Posted: Nov 19, 2018 9AM)
Current knowledge and recent insights into the genetic basis of amyotrophic lateral sclerosis.
Volk Alexander E et al. Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V 2018 30(2) 252-258
(Posted: Sep 19, 2018 9AM)
An Appalachian odyssey: Hunting for ALS genes along a sprawling family tree
E Boodman, Stat News, August 5, 2018
(Posted: Aug 06, 2018 8AM)
Initial Identification of a Blood-Based Chromosome Conformation Signature for Aiding in the Diagnosis of Amyotrophic Lateral Sclerosis.
Salter Matthew et al. EBioMedicine 2018 Jun
(Posted: Jun 27, 2018 9AM)
Genetic polymorphisms in amyotrophic lateral sclerosis: Evidence for implication in detoxification pathways of environmental toxicants.
Dardiotis Efthimios et al. Environment international 2018 Apr 122-135
(Posted: May 11, 2018 11AM)
May is ALS Awareness Month; the ALS Registry Offers Hope
(Posted: May 07, 2018 8AM)
Next Generation Sequencing and ALS: known genes, different phenotyphes.
Campopiano Rosa et al. Archives italiennes de biologie 2017 Dec (4) 110-117
(Posted: Mar 14, 2018 11AM)
The epidemiology and genetics of Amyotrophic lateral sclerosis in China.
Liu Xiaolu et al. Brain research 2018 Mar
(Posted: Mar 14, 2018 11AM)
Prevalence of Amyotrophic Lateral Sclerosis - United States, 2014.
Mehta Paul et al. MMWR. Morbidity and mortality weekly report 2018 Feb (7) 216-218
(Posted: Mar 14, 2018 11AM)
National ALS Biorepository
(Posted: Feb 19, 2018 1PM)
Motor Neuron Gene Therapy: Lessons from Spinal Muscular Atrophy for Amyotrophic Lateral Sclerosis.
Tosolini Andrew P et al. Frontiers in molecular neuroscience 2017 405
(Posted: Feb 06, 2018 0PM)
Causative Genes in Amyotrophic Lateral Sclerosis and Protein Degradation Pathways: a Link to Neurodegeneration.
Maurel C et al. Molecular neurobiology 2018 Jan
(Posted: Feb 06, 2018 0PM)
RNA-Targeted Therapies and Amyotrophic Lateral Sclerosis.
Mathis Stéphane et al. Biomedicines 2018 Jan (1)
(Posted: Feb 06, 2018 0PM)
Patients with sporadic and familial amyotrophic lateral sclerosis found value in genetic testing.
Wagner Karin N et al. Molecular genetics & genomic medicine 2017 Dec
(Posted: Jan 03, 2018 10AM)
CDC Grand Rounds: National Amyotrophic Lateral Sclerosis (ALS) Registry Impact, Challenges, and Future Directions.
Mehta Paul et al. MMWR. Morbidity and mortality weekly report 2017 Dec (50) 1379-1382
(Posted: Dec 28, 2017 10AM)
The Knowns and Unknowns about Amyotrophic Lateral Sclerosis (ALS)
CDC Environmental Health Blog, 2017
(Posted: Dec 14, 2017 7PM)
RNA-Seq reveals a novel therapeutic strategy for ALS treatment
RNA Seq Blog, Dec 12, 2017
(Posted: Dec 13, 2017 8AM)
Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort.
Garton Fleur C et al. Molecular genetics & genomic medicine 2017 Jul 5(4) 418-428
(Posted: Jul 26, 2017 9AM)
Genetic screening in sporadic ALS and FTD.
Turner Martin R et al. Journal of neurology, neurosurgery, and psychiatry 2017 Jun
(Posted: Jun 28, 2017 10AM)
Predictive genetic testing for amyotrophic lateral sclerosis and frontotemporal dementia: genetic counselling considerations.
Crook Ashley et al. Amyotrophic lateral sclerosis & frontotemporal degeneration 2017 Jun 1-11
(Posted: Jun 07, 2017 9AM)
Evaluating a Gene-Environment Interaction in Amyotrophic Lateral Sclerosis: Methylmercury Exposure and Mutated SOD1.
Bailey Jordan M et al. Current environmental health reports 2017 Jun (2) 200-207
(Posted: May 30, 2017 7AM)
A New Drug for A.L.S., but the Diagnosis Remains Dire
JE Brody, New York Times, May 29, 2017
(Posted: May 30, 2017 6AM)
Clinical Trials and Studies Using the National Amyotrophic Lateral Sclerosis Registry
(Posted: Apr 19, 2017 0PM)
Genetics insight into the amyotrophic lateral sclerosis/frontotemporal dementia spectrum.
Ji Ai-Ling et al. Journal of medical genetics 2017 Mar (3) 145-154
(Posted: Apr 04, 2017 9AM)
National Amyotrophic lateral sclerosis (ALS) Registry -- Impact, Challenges, and Future Directions
CDC Public Health Grand Rounds, April 18, 2017
(Posted: Apr 04, 2017 9AM)
Gene discovery in amyotrophic lateral sclerosis: implications for clinical management.
Al-Chalabi Ammar et al. Nature reviews. Neurology 2017 Feb (2) 96-104
(Posted: Feb 13, 2017 10AM)
Genetic testing in ALS: A survey of current practices.
Vajda Alice et al. Neurology 2017 Feb
(Posted: Feb 08, 2017 9AM)
Decoding ALS: from genes to mechanism
JP Taylor et al, Nature Insights, November 2016
(Posted: Nov 14, 2016 9PM)
Patients with Amyotrophic Lateral Sclerosis Have High Interest in and Limited Access to Genetic Testing.
Wagner Karin N et al. Journal of genetic counseling 2016 Oct
(Posted: Oct 26, 2016 10AM)
Pathogenesis of amyotrophic lateral sclerosis.
Morgan Sarah et al. British medical bulletin 2016 Sep (1) 87-98
(Posted: Oct 04, 2016 3PM)
Research funded by the National ALS Registry
(Posted: Oct 04, 2016 3PM)
ALS Registry Turns 6
(Posted: Oct 04, 2016 3PM)
ALS: A bucket of genes, environment, metabolism and unknown ingredients.
Zufiría Mónica et al. Progress in neurobiology 2016 Jul 104-29
(Posted: Aug 23, 2016 9AM)
National ALS Registry Releases Updated Prevalence Estimates
CDC press release, August 4, 2016
(Posted: Aug 06, 2016 10AM)
The Ice Bucket Challenge Helped Scientists Discover a New Gene Tied to A.L.S.
New York Times, July 27, 2016
(Posted: Jul 29, 2016 10AM)
From animal models to human disease: a genetic approach for personalized medicine in ALS
V Picher-Martel et al, Acta Neuropathologica CommunicationsNeuroscience of Disease20164:70
(Posted: Jul 25, 2016 8PM)
Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis
W van Rheenen et al, Nature Genetics, July 25, 2016
(Posted: Jul 25, 2016 8PM)
ALS: Recent Developments from Genetics Studies.
Therrien Martine et al. Current neurology and neuroscience reports 2016 Jun (6) 59
(Posted: Apr 30, 2016 8AM)
Announcement: Amyotrophic Lateral Sclerosis (ALS) Awareness Month May 2016
(Posted: Apr 30, 2016 8AM)
Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis
SW Song et al, Nature Medicine, February 29, 2016
(Posted: Feb 29, 2016 3PM)
Metabolomics in amyotrophic lateral sclerosis: how far can it take us?
Blasco H et al. European journal of neurology 2016 Jan
(Posted: Feb 24, 2016 1PM)
The interplay between metabolic homeostasis and neurodegeneration: insights into the neurometabolic nature of amyotrophic lateral sclerosis.
Ngo S T et al. Cell regeneration (London, England) 2015 (1) 5
(Posted: Oct 13, 2015 1PM)
Genotype-phenotype relationship in hereditary amyotrophic lateral sclerosis.
Yamashita Satoshi et al. Translational neurodegeneration 2015 13
(Posted: Oct 13, 2015 1PM)
Clinical Trials of Therapies for Amyotrophic Lateral Sclerosis: One Size Does Not Fit All.
Goutman Stephen A et al. JAMA neurology 2015 Jul (7) 743-4
(Posted: Oct 13, 2015 1PM)
Metabolomics of Neurodegenerative Diseases.
Botas Alejandro et al. International review of neurobiology 2015 53-80
(Posted: Oct 13, 2015 1PM)
Heritability of Amyotrophic Lateral SclerosisInsights From Disparate Numbers
RL McLaughlin et al. JAMA Neurology, June 1, 2015
(Posted: Jun 01, 2015 1PM)
Is Innate Immunity And Inflammasomes Involved In Pathogenesis of Amyotrophic Lateral Sclerosis (ALS)?
Volpe Caroline M O et al. Recent Pat Endocr Metab Immune Drug Discov 2015 Apr 7.
(Posted: May 12, 2015 7AM)
Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era.
Paez-Colasante Ximena et al. Nat Rev Neurol 2015 May (5) 266-279
(Posted: May 12, 2015 7AM)
Identification of rare protein disulfide isomerase gene variants in amyotrophic lateral sclerosis patients.
Gonzalez-Perez Paloma et al. Gene 2015 Apr 22.
(Posted: May 12, 2015 7AM)
The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease.
Lill Christina M et al. Alzheimers Dement 2015 Apr 29.
(Posted: May 12, 2015 7AM)
Whole genome analyses reveal no pathogenetic single nucleotide or structural differences between monozygotic twins discordant for amyotrophic lateral sclerosis.
Meltz Steinberg Karyn et al. Amyotroph Lateral Scler Frontotemporal Degener 2015 May 11. 1-8
(Posted: May 12, 2015 7AM)
Homozygosity mapping in an Irish ALS case-control cohort describes local demographic phenomena and points towards potential recessive risk loci.
McLaughlin Russell L et al. Genomics 2015 Apr (4) 237-41
(Posted: Apr 02, 2015 11AM)
ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP.
Sun Shuying et al. Nat Commun 2015 6171
(Posted: Apr 02, 2015 11AM)
Psychiatric genetics, neurogenetics, and neurodegeneration.
Kerner Berit et al. Front Genet 2014 467
(Posted: Apr 02, 2015 11AM)
Network Analyses Reveal Novel Aspects of ALS Pathogenesis.
Sanhueza Mario et al. PLoS Genet. 2015 Mar (3) e1005107
(Posted: Apr 02, 2015 11AM)
Exome sequencing of case-unaffected-parents trios reveals recessive and de novo genetic variants in sporadic ALS.
Steinberg Karyn Meltz et al. Sci Rep 2015 9124
(Posted: Apr 02, 2015 11AM)
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways.
Cirulli Elizabeth T et al. Science 2015 Mar 27. (6229) 1436-1441
(Posted: Apr 02, 2015 11AM)
CDC Information: National ALS Registry Makes a Difference
(Posted: Feb 25, 2015 0PM)
National Amyotrophic Lateral Sclerosis (ALS) Registry
(Posted: Feb 25, 2015 0PM)
Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS.
Smith Bradley N et al. Neuron 2014 Oct 22. (2) 324-31
(Posted: Feb 23, 2015 10AM)
Amyotrophic Lateral Sclerosis Genetic Studies: From Genome-wide Association Mapping to Genome Sequencing.
He Ji et al. Neuroscientist 2014 Nov 5.
(Posted: Feb 23, 2015 10AM)
Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes.
Cady Janet et al. Ann. Neurol. 2015 Jan (1) 100-13
(Posted: Feb 23, 2015 10AM)
A second-generation Irish genome-wide association study for amyotrophic lateral sclerosis.
McLaughlin Russell L et al. Neurobiol. Aging 2015 Feb (2) 1221.e7-1221.e13
(Posted: Feb 23, 2015 10AM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2024
- Page last updated:May 03, 2024
- Content source: